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FISH Alternative Promising for Aneuploidy Search.

RANCHO MIRAGE, CALIF. -- A relatively new technique called comparative genomic hybridization may soon replace fluorescent in situ hybridization as the method of choice for obtaining preimplantation genetic diagnoses for aneuploidy in blastomeres.

Comparative genomic hybridization (CGH) is a molecular cytogenic technique that enables simultaneous enumeration of every chromosome, in contrast to fluorescent in situ hybridization (FISH), which at present can karyotype only a maximum of nine chromosomes, Leeanda Wilton, Ph.D., said at the annual meeting of the Pacific Coast Reproductive Society.

The technique was originally developed to look for aneuploidies in tumor cells. ...

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