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Article: Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor beta.(Abstract)
- Article from:
- Alternative Medicine Review
- Article date:
- August 1, 2001
CopyrightCOPYRIGHT 2001 Thorne Research Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor beta. Kim H, Xu J, Su Y, et al. Biochem Soc Trans 2001;29:216-222.
The structural similarity, but non-identity, between 17beta-oestradiol and the soy phytoestrogen genistein suggests that the two compounds will have actions that may be identical in some target biological systems, but different in others. Epidermal growth factor (EGF)-stimulated proliferation of human mammary epithelial cells (that do not express the oestrogen receptor) was significantly suppressed at genistein concentrations (5-10 microM) that are attainable ...