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Article: Low-Dose Topotecan Augments Antibodies Against VEGF In Wilms Tumor.(Brief Article)
- Article from:
- Cancer Weekly
- Article date:
- October 2, 2001
CopyrightCOPYRIGHT 2001 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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2001 OCT 2 - (NewsRx.com & NewsRx.net) --
by Sonia Nichols, senior medical writer - Researchers say topotecan, a cancer drug, enhances the effectiveness of antibody to vascular endothelial growth factor (VEGF) in murine models of Wilms tumor.
This same combination of therapies might also be of use for humans with Wilms tumor, a type of kidney cancer that develops most often in children.
"Antibody to vascular endothelial growth factor (anti-VEGF) suppresses tumor growth and metastasis in experimental Wilms tumor. However, tumor growth accelerates if antibody is withdrawn," S.Z. Soffer and colleagues of Babies and Children's Hospital of New York ...
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