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Article: Langerhans Cells Express Functional CXCR4.(Brief Article)
- Article from:
- AIDS Weekly
- Article date:
- October 8, 2001
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2001 OCT 8 - (NewsRx.com & NewsRx.net) --
by Michael Greer, senior medical writer - Human Langerhans cells express a functional HIV coreceptor, a finding that may help clarify the mechanisms of HIV transmission, according to researchers in France.
"HIV can cross the intact epithelium of genital mucosae via Langerhans cells," explained Prof. Christian Genin and colleagues at the University of Saint-Etienne in Lyon. "The presence of CXCR4 on the surface of cultured but not freshly isolated Langerhans cells has been described."
Genin and research team showed that fresh Langerhans cells did, in fact, express this coreceptor and that disruption of ...