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Article: ABRA Protein Fragments Halt P. falciparum Growth.
- Article from:
- TB & Outbreaks Week
- Article date:
- September 18, 2001
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2001 SEP 18 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer - The acidic basic repeat antigen (ABRA) of Plasmodium falciparum stops 80%-90% of parasite growth and represents a promising vaccine candidate, researchers in India have found.
"The recombinant proteins representing different fragments of ABRA were expressed in Escherichia coli, either as fusions with maltose binding protein or as 6X histidine tagged molecules, and purified by affinity chromatography," reported A. Kushwaha and colleagues in New Delhi.
Animal studies using these constructs indicated that the N-terminal region is the least immunogenic part of ABRA and that ...