|
|
Article: Up-regulation of integrins [[alpha].sub.3] [[beta].sub.1] in sulfate-starved marine sponge cells: functional correlates.
- Article from:
- The Biological Bulletin
- Article date:
- October 1, 2001
- Author:
CopyrightCOPYRIGHT 2001 Marine Biological Laboratory. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
William J. Kuhns (1)
Dario Rusciano (2)
Jane Kaltenbach (3)
Michael Ho (1)
Max Burger (2)
Xavier Fernandez-Busquets (4)
Integrins are a large family of heterodimeric transmembrane glycoproteins that attach cells to fibronectin and collagen and other extracellular matrix proteins of the basement membrane. The attachment is by way of recognition sequences--RGD in the case of fibronectin. The transmembrane and cytoplasmic domains of integrins provide a conduit for outside-in as well as inside-out signaling (1). Integrins or their domains have been highly conserved over many millions of years as judged from their ...