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Article: Lt[B.sub.4] evokes the calcium signal that initiates nuclear envelope breakdown through a multi-enzyme network in sand dollar (echinaracnius parma) cells.
- Article from:
- The Biological Bulletin
- Article date:
- October 1, 2001
- Author:
CopyrightCOPYRIGHT 2001 Marine Biological Laboratory. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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In our ongoing study of cell division control, we have shown that a calcium signal that is required for mitosis and that precedes nuclear envelope breakdown (NEB) arises from perinuclear endomembrane vesicles which are derived from a subset of the endoplasmic reticulum (1-5). Analyses of the calcium signals indicate that 1) this pre-NEB calcium signal occurs in microdomains; 2) the signals emitted at individual microdomains are not coherent; and 3) neither calcium nor its agonist diffuses more than 1 [micro]m from the site of agonist production and calcium release (4, 6, 7). Prompted by those analyses, we posited and subsequently showed that leukotriene [B.sub.4] ...