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Article: Formation of strong airway irritants in mixtures of isoprene/ozone and isoprene/ozone/nitrogen dioxide. (Articles).
- Article from:
- Environmental Health Perspectives
- Article date:
- September 1, 2001
- Author:
CopyrightCOPYRIGHT 2001 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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We evaluated the airway irritation of isoprene, isoprene/ozone, and isoprene/ozone/nitrogen dioxide mixtures using a mouse bioassay, from which we calculated sensory irritation, bronchial constriction, and pulmonary irritation. We observed significant sensory irritation (approximately 50% reduction of mean respiratory rate) by dynamically exposing the mice, over 30 min, to mixtures of isoprene and [O.sub.3] or isoprene, [O.sub.3], and N[O.sub.2]. The starting concentrations were approximately 4 ppm [O.sub.3] and 500 ppm isoprene (+ approximately 4 ppm N[O.sub.2]). The reaction mixtures after approximately 30 sec contained
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