Article: The facts on antibiotic conversion therapy: Newer antimicrobial agents have revolutionized conversion therapy. Decisions are now made based on solid pharmacokinetic and pharmacodynamic data rather than empirically.

Increasing microbial resistance to antibiotic therapy and the rising cost of drugs in the United States have forced providers to identify ways to optimize patient care and resources, reduce costs, and minimize the spread of antimicrobial resistance. Because hospitals spend more on IV antimicrobial agents than on any other class of drug, (1) one target has been the common practice of using parenteral antimicrobial therapy in severe or life-threatening infection while reserving oral therapy for mild or moderate infection. This article reviews the historical practice and current and past literature regarding early conversion of antimicrobial agents from IV administration to ...

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