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Article: Urinary Bladder Approach Could Be Used For Vaccinia-Mediated Therapy.(Brief Article)
- Article from:
- Vaccine Weekly
- Article date:
- December 26, 2001
CopyrightCOPYRIGHT 2001 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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2001 DEC 26 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - The results of a Phase I trial indicate urinary bladder cancer and other diseases of the urinary tract could be treated by directly infecting the bladder with vaccinia virus, the same virus used in vaccines for preventing smallpox.
The properties of vaccinia virus make it a good candidate for use in bladder-directed gene therapies, according to Leonard G. Gomella and colleagues, Thomas Jefferson University, Philadelphia, Pennsylvania.
"The virus has a high efficiency of infection, replicates in the cytoplasm without chromosomal integration, and can transport a large ...