|
|
Article: Influence of platelet collagen receptor polymorphisms on risk for arterial thrombosis. (Advances in the Science of Pathology).
- Article from:
- Archives of Pathology & Laboratory Medicine
- Article date:
- March 1, 2002
- Author:
CopyrightCOPYRIGHT 2002 College of American Pathologists. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
The initial events in vascular thrombosis are platelet adhesion to collagen and collagen-induced platelet activation. Three receptors play pivotal roles in the initiation of platelet adhesion to collagen: the glycoprotein (GP) Ib-IX-V complex (GPIb complex), the integrin [[alpha].sub.2][[beta].sub.1], and GPVI. Any variation in the expression or function of these collagen receptors may lead to excessive bleeding or thrombus formation in pathologic conditions. In this regard, we first reported significant variations in both function and antigen levels of integrin [[alpha].sub.2][[beta].sub.1] on platelets from normal subjects. (1) We have shown that the level of platelet ...
Related newspaper, magazine, and journal articles:
|