Article: Influence of platelet collagen receptor polymorphisms on risk for arterial thrombosis. (Advances in the Science of Pathology).

The initial events in vascular thrombosis are platelet adhesion to collagen and collagen-induced platelet activation. Three receptors play pivotal roles in the initiation of platelet adhesion to collagen: the glycoprotein (GP) Ib-IX-V complex (GPIb complex), the integrin [[alpha].sub.2][[beta].sub.1], and GPVI. Any variation in the expression or function of these collagen receptors may lead to excessive bleeding or thrombus formation in pathologic conditions. In this regard, we first reported significant variations in both function and antigen levels of integrin [[alpha].sub.2][[beta].sub.1] on platelets from normal subjects. (1) We have shown that the level of platelet ...

Related newspaper, magazine, and journal articles:

 
 
Newsweek Harper's Magazine The Washington Post Chicago Tribune Crain's Chicago Business PRNewswire Pediatric News The Nation Advertising Age The Economist (US) A FREE trial gives you access to over 80 million articles! Access over 6,500 publications with a FREE trial!