Article: Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease.(Abstract)

Quinlivan EP, McPartlin J, McNulty H, et al. Lancet 2002;359:227-228.

Fortification of food with folic acid to prevent neural-tube defects in babies also lowers plasma total homocysteine, which is a risk factor for vascular disease. We investigated the effect of folate and vitamin B12 on homocysteine concentrations. 30 men and 23 women received sequential supplementation with increasing doses of folic acid. After supplementation, the usual dependency of ...

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