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Article: MYCC and MYCN oncogene amplification in medulloblastoma: a fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. (Original Articles).
- Article from:
- Archives of Pathology & Laboratory Medicine
- Article date:
- May 1, 2002
- Author:
CopyrightCOPYRIGHT 2002 College of American Pathologists. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Molecular genetic alterations have been used to provide information concerning patient prognosis in several common cancers. The most common alterations found to date involve inactivation of tumor suppressor genes via deletions, mutations, and/or hypermethylation of promoter regions and hyperexpression of oncogenes via amplifications of genetic material. Medulloblastoma is the second most common central nervous system tumor in children. The most common chromosomal abnormality in medulloblastoma is the deletion of the short arm of chromosome 17. Overexpression of certain oncogenes seems to play an important role in the pathogenesis of this tumor. (1,2) Anecdotal data and ...
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