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Article: Renal effects of uranium in drinking water. (Articles).
- Article from:
- Environmental Health Perspectives
- Article date:
- April 1, 2002
- Author:
CopyrightCOPYRIGHT 2002 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Animal studies and small studies in humans have shown that uranium is nephrotoxic. However, more information about its renal effects in humans following chronic exposure through drinking water is required. We measured uranium concentrations in drinking water and urine in 325 persons who had used drilled wells for drinking water. We measured urine and serum concentrations of calcium, phosphate, glucose, albumin, creatinine, and [beta]-2-microglobulin to evaluate possible renal effects. The median uranium concentration in drinking water was 28 [micro]g/L (interquartile range 6-135, max. 1,920 [micro]g/L) and in urine 13 ng/mmol creatinine (2-75), resulting in the median ...