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Article: Hydroxylated polychlorinated biphenyls as inhibitors of the sulfation and glucuronidation of 3-hydroxy-benzo[a]pyrene. (Articles).
- Article from:
- Environmental Health Perspectives
- Article date:
- April 1, 2002
- Author:
CopyrightCOPYRIGHT 2002 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Polychlorinated biphenyls (PCBs) can be metabolized by cytochromes P450 to hydroxylated biotransformation products. In mammalian studies, some of the hydroxylated products have been shown to be strong inhibitors of steroid sulfotransferases. As a part of ongoing research into the bioavailability of environmental pollutants in catfish intestine, we investigated the effects of a series of hydroxylated PCBs (OH-PCBs) on two conjugating enzymes, phenol-type sulfotransferase and glucuronosyltransferase. We incubated cytosolic and microsomal samples prepared from intestinal mucosa with 3-hydroxy-benzo[a]pyrene and appropriate cosubstrates and measured the effect of OH-PCBs on ...
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Article: PCBs in Housatonic ducks prompt state food warning
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August 28, 1999 ;
700+ words
... ... waterfowlers hunt in the Berkshires. PCBs, or polychlorinated biphenyls ... from the 1930s until 1977, when PCBs were banned, and it has long ... birds, while others said, "Oh, my God, I'm really worried ... Public Health explained that PCBs, which accumulate over time ...
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