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Article: DC-SIGN intercellular interactions not crucial for transmission.(Brief Article)
- Article from:
- Virus Weekly
- Article date:
- June 11, 2002
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2002 JUN 11 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States have cast doubt on a putative mechanism for intracellular HIV transmission.
"DC-SIGN, a type II membrane-spanning C-type lectin that is expressed on the surface of dendritic cells (DC), captures and promotes human and simian immunodeficiency virus (HIV and SIV) infection of CD4[superscript]+ T cells in trans," explained Dr. Li Wu and colleagues at the National Cancer Institute in Frederick, Maryland, Vanderbilt University in Nashville, Tennessee, and ICOS Corporation in Bothell, Washington.
Although DC-SIGN-mediated viral transmission ...