Article: Grapefruit juice does not affect amprenavir levels.(Brief Article)

2002 JUN 24 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - The HIV protease inhibitor amprenavir may be safely taken with grapefruit juice, researchers in France report.

Dr. D. Demarles and colleagues at the GlaxoSmithKline Laboratory in Marly-le-Roi and Bicetre Hospital in Paris evaluated the effects of grapefruit juice on circulating amprenavir levels.

Despite the concerns of some researchers, grapefruit juice does not have a significant effect on the pharmacokinetics of amprenavir, Demarles and coauthors found.

They examined amprenavir levels in 12 HIV[superscript]- volunteers who were given a single 1200 mg dose of ...

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