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Article: Calcium-fortified orange juice blocks absorption of ciprofloxacin. (Literature Review & Commentary).(Brief Article)
- Article from:
- Townsend Letter for Doctors and Patients
- Article date:
- July 1, 2002
- Author:
CopyrightCOPYRIGHT 2002 The Townsend Letter Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Fifteen healthy volunteers participated in a randomized, crossover study in which they consumed single doses of oral ciprofloxacin with water, with orange juice, and with calcium-fortified orange juice. Compared with water, the peak serum concentration (Cmax) of ciprofloxacin was significantly lower when the drug was given with orange juice (-23%; p = 0.001) and with calcium-fortified orange juice (-41%; p
Comment: Current FDA labeling states that ciprofloxacin and most other fluoroquinolones are safe to take with food and dietary calcium but not with calcium supplements. The results of the present study indicate that calcium-fortified orange juice behaves more like a ...