Article: Xenon Genetics Reports Scientific Advancement in HDL-Cholesterol Program.

VANCOUVER, British Columbia -- Xenon Genetics Inc. announced today that its research team together with collaborators have demonstrated that the gene (ABCA1) responsible for regulating levels of HDL- cholesterol (or "good-cholesterol") plays an important role in protecting against cardiovascular disease. Xenon's research showed that mice over- expressing human ABCA1 had a marked reduction in atherosclerosis compared with mice where human ABCA1 was not over-expressed. These findings appear in the July 1st issue of The Journal of Clinical Investigation (JCI).

Xenon's HDL program is based on the company's discovery of the ABCA1 gene as a major regulator of reverse ...

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