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Article: Estrogen tied to increased risk of ovarian cancer: some are questioning the study's design and incomplete data on family history. (44,241 Women Studied).
- Article from:
- OB GYN News
- Article date:
- August 15, 2002
- Author:
CopyrightCOPYRIGHT 2002 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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A new study deals yet another blow to hormone replacement therapy by suggesting that long-term use of unopposed estrogen is associated with a significantly increased risk of ovarian cancer, but some experts are questioning its conclusions.
Of 44,241 women followed for a mean of about 13 years, 329 developed ovarian cancer. The use of combination hormone replacement therapy (HRT) was not associated with ovarian cancer. However, the rate of ovarian cancer among women who had ever used unopposed estrogen replacement therapy (ERT) was 60% higher than in women who had never used ERT, representing a rate ratio of 1.6. The rate ratio was 1.8 in women who had been on ERT ...