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Article: Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy.(Brief Article)
- Article from:
- Alternative Medicine Review
- Article date:
- August 1, 2002
- Author:
CopyrightCOPYRIGHT 2002 Thorne Research Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Vihtamaki T, Parantainen J, Koivisto AM, et al. Maturitas 2002;42:129-135.
OBJECTIVES: To study the possible interaction between ascorbic acid (AA) and oestradiol (E2) in postmenopausal women on hormone replacement therapy (HRT). METHODS: We studied 25 healthy postmenopausal women who had used percutaneous E2 gel at same dose for 10-12 months, at which time the plasma E2 concentrations were stabilized. The subjects were treated with 1000 mg of AA daily for 3 months and blood samples for assay of AA and E2 were taken at 0, 1 and 3 months. RESULTS: After 1 month of AA treatment, there was an overall increase of 20.8% in E2 levels in the group as a whole. Greater ...