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Article: Estrogenicity of styrene oligomers and assessment of estrogen receptor binding assays. (Correspondence).
- Article from:
- Environmental Health Perspectives
- Article date:
- July 1, 2002
- Author:
CopyrightCOPYRIGHT 2002 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Polystyrene is frequently used in resins, and the styrene dimers and trimers eluted from polystyrene have been reported to have estrogenic activity (1). We have performed a number of in vitro and in vivo tests [i.e., estrogen receptor (ER) and androgen receptor binding assays, thyroid hormone receptor binding assays, human breast cancer cell line MCF-7 proliferation assays (E-SCREEN), uterotrophic assays in immature and ovariectomized rats, Hershberger assays, and prolactin release assays and steroidogenesis] and found no effects of styrene dimers or trimers on sex hormones in any of these assays (2-7). These results are supported by Fail et al. (8), who reported that ...