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Article: Estrogenicity of styrene oligomers: response to Ohno et al. (Correspondence).
- Article from:
- Environmental Health Perspectives
- Article date:
- July 1, 2002
- Author:
CopyrightCOPYRIGHT 2002 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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The main point of the letter by Ohno et al. is that styrene oligomers have no estrogenic activity, that our statement about "some styrene oligomers having binding affinity for hER[alpha]" was inaccurate, and that the MCF-7 cell proliferation assay is useless in detecting estrogenicity.
It seems that Ohno et al. have misunderstood our article. We are confident that the results of the MCF-7 cell proliferative assay and the binding assay of styrene oligomers to hER[alpha] in our paper are accurate.
The inhibition of fluorescence-labeled [E.sub.2] binding to hER[alpha] by styrene oligomers tested is shown in Figure 3 of our paper (1). The inhibition by ...