Article: Combined HRT not linked to endometrial hyperplasia. (Long-Term Continuous TX).

Postmenopausal women who used continuous combined hormone replacement therapy for up to 5 years were not at increased risk for endometrial hyperplasia or malignancy in a prospective, long-term follow-up study.

Moreover, the therapy was associated with some protective benefits, Dr. Michael Wells of the University of Sheffield (England) and his colleagues reported.

After an average duration of 4.4 years of hormone replacement therapy (HRT) use, endometrial histology in 534 postmenopausal women revealed that none of those with an assessable uterus had endometrial hyperplasia or malignancy including 21 who had been diagnosed with complex hyperplasia before ...

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