Article: Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content.

M. Sandoval (1), N. N. Okuhama (1), X.-J. Zhang (1), L. A. Condezo (2), J. Lao (2), F. M. Angeles (1), R. A. Musah (3), P. Bobrowski (4), and M. J. S. Miller (1)

Summary

Cat's claw is an herbal medicine from the Amazon that is used widely to treat inflammatory disorders. The purpose of this study was to characterize the antioxidative and antiinflammatory properties of cat's claw, Uncaria tomentosa (UT) and Uncaria guianensis (UG). Alkaloids and flavanols were determined using reversed-phase HPLC; scavenging of 1,1-diphenyl-2-picrilhydrazyl (DPPH), hydroxyl radicals, and lipid peroxidation by spectrophotometry; and TNF[alpha] production by ELISA. ... <0.01). The total oxindole and pentacyclic alkaloid content of UT was 35-fold>

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