Article: Culture method for in vitro fertilization to hatching of the squid, Loligo pealeii.

Much of what we know about cephalopod development is drawn from observing embryos in, or dissected from, naturally laid jelly strings or egg capsules (1, 2). Although embryos extracted from jelly strings survive in culture for short periods (3), reliable in vitro fertilization and culture would greatly enhance our ability to study the molecular and cellular events of fertilization and development, including pronuclear migration (4), cleavage (5), cytoplasmic movements (6), differentiation, and organogenesis. When in vitro fertilized embryos are cultured in glassware or plastic petri dishes, their development is typically arrested at the early blastoderm stage (

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