Article: Long-term combined HRT may raise leiomyoma risk. (Patients with Low BMI).

CHICAGO -- Long-term use of combined hormone replacement therapy was associated with a 70% increased risk of uterine leiomyoma in peri- and postmenopausal patients in a recent case-control study.

The study--said to be the first to look specifically at the association between leiomyoma formation and prior HRT use--involved 256 women with a confirmed first case of leiomyoma and 276 control patients in the same age range who had no previous diagnosis of leiomyoma. Long-term use of HRT was defined as at least 5 years, Dr. Susan D. Reed reported at the annual meeting of the North American Menopause Society.

The association between use of HRT and leiomyoma ...

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