|
|
Article: Mutation in DKC1 Gene Can Cause Rare Aging Disease, Cancer; May Suggest New Target for Drug Treatment.
- Article from:
- Ascribe Higher Education News Service
- Article date:
- January 9, 2003
CopyrightCOPYRIGHT 2003 AScribe. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
Byline: Memorial Sloan-Kettering Cancer Center
NEW YORK, Jan. 9 (AScribe Newswire) -- A rare genetic syndrome, Dyskeratosis Congenita (DC), may hold the key to understanding a mechanism that causes premature aging and cancer. Recreating DC in genetically altered "knockout" mice, researchers at Memorial Sloan-Kettering Cancer Center and colleagues proved that the disorder was caused, as theorized, by mutations in the DKC1 gene. Unexpectedly, they also showed that DC was caused by a disruption in ribosome function and not due to shortened telomeres (the distal end of a chromosome arm) as previously hypothesized. Their results, published in the January 10 issue of ...