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Article: Common factors influence target site selection of many transposable elements.
- Article from:
- Gene Therapy Weekly
- Article date:
- January 16, 2003
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2003 JAN 16 - (NewsRx.com & NewsRx.net) -- According to a recent study, "Sleeping Beauty (SB) is the most active Tc1/mariner-type transposable element in vertebrates, and is therefore a valuable vector for transposon mutagenesis in vertebrate models and for human gene therapy."
T.J. Vigdal and colleagues, Max Delbruck Center for Molecular Medicine, Berlin, Germany, "have analyzed factors affecting target site selection of SB in mammalian cells by generating transposition events from extrachromosomal plasmids to chromosomes.
They reported that, "[i]n contrast to the local hopping observed when transposition is induced from a chromosomal context, mapping ...