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Article: Ca[superscript]2+ alternans represents mechanism for generation of arrhythmogenic waves.
- Article from:
- Heart Disease Weekly
- Article date:
- February 16, 2003
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2003 FEB 16 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Ca[superscript]2+ alternans is a potentially arrhythmogenic beat-to-beat alternation of the amplitude of the action potential-induced [Ca[superscript]2+][subscript]i transient in cardiac myocytes. Despite its pathophysiological significance the cellular mechanisms underlying Ca[superscript]2+ alternans are poorly understood. Recent evidence, however, points to the modulation of Ca[superscript]2+-induced Ca[superscript]2+ release (CICR) from the sarcoplasmic reticulum(SR) by localized alterations in energy metabolism as an important determinant of Ca[superscript]2+ alternans.
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