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Article: A-kinase anchoring protein found associated to axonemes; role in beat likely.
- Article from:
- Proteomics Weekly
- Article date:
- February 17, 2003
CopyrightCOPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "although protein kinase A (PKA) activation is known to increase ciliary beat frequency in humans, the molecular mechanisms involved are unknown. We demonstrate that PKA is associated with ciliary axonemes where it specifically phosphorylates a 23-kDa protein. Because PKA is often localized to subcellular compartments in proximity to its substrate(s) via interactions with A-kinase anchoring proteins (AKAPs), we investigated whether an AKAP was also associated with ciliary axonemes. This study has identified a novel 28 kDa AKAP (AKAP28) that is highly enriched in airway axonemes.
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