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Article: Shock waves could deliver ribosome-inactivating cytotoxin to cancer cells.(colorectal and ovarian cancer therapy)(Brief Article)
- Article from:
- Cancer Weekly
- Article date:
- February 18, 2003
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2003 FEB 18 - (NewsRx.com & NewsRx.net) -- "We report on the use of shock waves delivered by a shock tube to permeabilize cancer cells and potentiate the cytotoxicity of the type-1 ribosome inactivating protein, saporin. We studied human colorectal cancer HT29 and ovarian cancer OVCAR-5 cells, and used two different cytotoxicity assays: colony formation and loss of mitochondrial activity. A single shock wave and saporin (10[superscript]-9M) produced significant toxicity not seen with either shock wave or drug alone," researchers in the United States report.
"Increasing the number up to 5 shock waves further increased cytotoxicity. Higher toxicity was seen with ...