Article: Smallpox vaccine: does it work?

The debate over use of the smallpox vaccine has focused on the risks of side effects and deaths caused by the vaccine, as well as the problems associated with the vaccine's outmoded technology, but these discussions have ignored questions about the vaccine's effectiveness. Authorities insist that smallpox vaccine was responsible for eradication of one of humanity's greatest scourges (WHO, 1980). It may therefore come as a tremendous surprise that throughout the nearly 200-year history of smallpox vaccination, thoughtflul physicians and a veritable army of citizens doubted that the vaccine worked at all.

Four factors have contributed to skepticism of smallpox ...

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