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Article: GlcNH[subscript]2 residues in heparin sulfate formed by incomplete action of enzyme.
- Article from:
- Drug Week
- Article date:
- February 28, 2003
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2003 FEB 28 - (NewsRx.com & NewsRx.net) -- Structural characterization of sequences around rare N-unsubstituted glucosamine (GlcNH[subscript]2) residues in native heparan sulfate has been pursued by biochemists in Sweden.
"Functional properties of heparan sulfate (HS) are generally ascribed to the sulfation pattern of the polysaccharide. However, recently reported functional implications of rare N-unsubstituted glucosamine (GlcNH[subscript]2) residues in native HS prompted our structural characterization of sequences around such residues," said C. Westling and colleagues, Uppsala University.
"HS preparations were cleaved with nitrous acid at either ...