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Article: Systemic disorders and their rheumatic manifestations.
- Article from:
- Genomics & Genetics Weekly
- Article date:
- March 7, 2003
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2003 MAR 7 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "The authors review the genes, and their respective proteins, responsible for eight autoinflammatory conditions.
"Familial Mediterranean fever is caused by mutations in pyrin, which is the prototype of a new family of proteins belonging to the death-domain superfamily. This new group of proteins, which regulate apoptosis, inflammation, and cytokine processing, share an approximately 90-amino-acid N-terminal sequence called the PYRIN domain.
"Mutations in another PYRIN domain protein, termed cryopyrin, are responsible for three clinically defined illnesses, ...