|
|
Article: Sodium channel localization in intercalated disks modulates cardiac conduction.
- Article from:
- Heart Disease Weekly
- Article date:
- March 9, 2003
CopyrightCOPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
2003 MAR 9 - (NewsRx.com & NewsRx.net) -- According to a study in Switzerland, "It is well known that the sodium current (I-Na) and the degree of gap junctional electrical coupling are the key determinants of action potential (AP) conduction in cardiac tissue. Immunohistochemical studies have shown that sodium channels (NaChs) are preferentially located in intercalated disks (IDs).
"Using dual immunocytochemical staining, we confirmed the colocalization of NaChs with connexin43 in cultures of neonatal rat ventricular myocytes.
"In mathematical simulations of conduction using the Luo-Rudy dynamic model of the ventricular AP, we assessed the hypothesis ...