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Article: DAT optimizes dopaminergic transmission in synaptic cleft during degeneration.
- Article from:
- Immunotherapy Weekly
- Article date:
- March 5, 2003
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2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "We have evaluated the ability of the injured nigrostriatal dopaminergic system to produce highly reactive hydroxyl radicals ((OH)-O-.) by the electrochemical detection of salicylate hydroxylation.
"Unilateral transection of the medial forebrain bundle transiently increased the formation of (OH)-O- in substantia nigra (SN) but not in striatum during the first 48 h postlesion, when most relevant changes in terms of oxidatively modified proteins take place," researchers in Spain report.
"Short-term adaptive axotomy-induced changes in substantia nigra included downregulation of nigral tyrosine hydroxylase (TH) and ...