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Article: IL-6 enhances IgE-dependent histamine release from peripheral blood mast cells.
- Article from:
- Blood Weekly
- Article date:
- March 20, 2003
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2003 MAR 20 - (NewsRx.com & NewsRx.net) -- Interleukin (IL)-6 enhances immunoglobulin E (IgE)-dependent histamine release from peripheral blood mast cells.
Researchers in Japan investigated whether IL-6 "exerts the stimulatory effects on the secretion of histamine from human mast cells triggered by crosslinking of the high affinity IgE receptor (FcepsilonRI) with IgE and anti-IgE."
"As target cells, we used peripheral blood-derived cultured mast cells grown with SCF [stem cell factor], because they were superior in FcepsilonRIalpha expression to cord blood-derived mast cells," according to T. Kikuchi and colleagues, Shinshu University.
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