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Article: Gadolinium cationic lipids are new tools for transfection.
- Article from:
- Gene Therapy Weekly
- Article date:
- March 20, 2003
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2003 MAR 20 - (NewsRx.com & NewsRx.net) -- Gadolinium cationic lipids are new tools for transfection.
According to a study from France, "gadolinium-chelating cationic lipids have been synthesized to obtain lipoplexes with MRI contrast properties. These compounds were designed to follow the biodistribution of synthetic DNA for gene delivery by nuclear magnetic resonance imaging."
"The lipid MCO-I-68 was synthesized, and chelate complexes with gadolinium were formed and characterized in terms of physicochemical and DNA binding properties," wrote F. Leclercq and coauthors, ENSCP.
"The transfection activity of MCO-I-68-Gd/DNA complexes was ...