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Article: Tobacco smoke and formation of N-(2-hydroxyethyl)valine in human hemoglobin.(cigarette smoke and cancer risk)
- Article from:
- Archives of Environmental Health
- Article date:
- September 1, 2002
- Author:
CopyrightCOPYRIGHT 2002 Heldref Publications. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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HUMAN EXPOSURE TO ETHYLENE OXIDE (EtO) occurs mainly through inhalation of polluted air (1,2) in occupational workplaces and/or via tobacco smoke. (3) EtO is also produced within the human body as a metabolic activation product of ethylene, (4) which is a common urban air pollutant (5,6) and a component of the gaseous phase of tobacco smoke. (3) Epidemiological studies in occupationally EtO-exposed humans have shown that this epoxide represents a definite risk factor for leukemia and a possible risk factor for solid tumors. These risks represent 1 component of the overall carcinogenic risk to humans of tobacco smoke (both active and passive). (6-9)
EtO is an ...
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