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Article: Aldehyde dehydrogenase genes specialized for beta-alanine biosynthesis in yeast.
- Article from:
- Genomics & Genetics Weekly
- Article date:
- April 18, 2003
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2003 APR 18 - (NewsRx.com & NewsRx.net) -- A study by Bristol Myers Squibb Co. chemists demonstrated that in the familiar yeast, Saccharomyces cerevisiae, aldehyde dehydrogenase genes ALD2 and ALD3 are specialized for beta-alanine biosynthesis, and so play a role in cellular biosynthesis of coenzyme A.
"The amino acid beta-alanine is an intermediate in pantothenic acid (vitamin B-5) and coenzyme A (CoA) biosynthesis. In contrast to bacteria, yeast derive the beta-alanine required for pantothenic acid production via polyamine metabolism, mediated by the four SPE genes and by the FAD-dependent amine oxidase encoded by FMS1," said W.H. White and colleagues.