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Article: Infection spread inhibited by DNA immunization with C. trachomatis pgp3 gene.(Brief Article)
- Article from:
- Vaccine Weekly
- Article date:
- April 16, 2003
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2003 APR 16 - (NewsRx.com & NewsRx.net) -- In experiments with C3H/HeN mice, DNA immunization with the pgp3 gene of "Chlamydia trachomatis inhibited spread of the bacterial infection from the lower genital tract to the upper.
M. Donati and coauthors, University of Bologna, infected 300 "Chlamydia trachomatis pgp3 DNA-immunized and [300] non-immunized C3H/HeN mice ... by vaginal inoculation with infectious C. trachomatis serotype D elementary bodies (EB3s)."
They "[assessed] the spread of infection to the salpinges ... by cell culture isolation from tissue homogenates 7, 14, 21, 28, 35 and 42 days post-infection (p.i.)."
The researchers ...