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Article: Drug Interaction and the Brain
- Article from:
- Encyclopedia of Drugs, Alcohol, and Addictive Behavior
- Author:
CopyrightCOPYRIGHT 2001 The Gale Group Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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DRUG INTERACTION AND THE BRAIN
When two or more drugs are taken at the same time complex interactions may occur. Drugs can interact to change biological functions within the body through Pharmacokinetic or Pharmacodynamic mechanisms or through their combined toxic effects. Changes in the pharmacokinetic properties of a drug can include changes in absorption, distribution, metabolism, and excretion of the drug, and each of these can affect blood and plasma concentrations and, ultimately, brain levels of the drug. Although a change in the speed at which a drug reaches the bloodstream is rarely clinically relevant, a change in the amount of drug absorbed can be important, because this can ...
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