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Altretamine
- Article from:
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Gale Encyclopedia of Cancer
- Author:
- Zuck, Michael
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Copyright informationCOPYRIGHT 2002 The Gale Group Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Altretamine
Definition
Altretamine, also known by the brand name Hexalen, is an anticancer agent used to treat
ovarian cancer
.
Purpose
Altretamine is used to treat persistent or recurrent ovarian cancer, usually after treatment of the cancer with
cisplatin
and/or an alkylating agent fails to effectively treat the tumor.
Description
The mechanism of action of altretamine is not known. However, it is thought that it may inhibit DNA and RNA synthesis.
Recommended dosage
Alretamine is administered orally. Doses for the drug may be different depending on the protocol that is used by the physician. Some example dosing regimens are: 4 to 12 mg per kg in three to four divided ...