Article: Suzuki FXR 150

Article: Research in the area of inflammation reported from Y.D. Wang and colleagues.
Biotech Week;  December 24, 2008 ;     455 words ......United States, The farnesoid X receptor (FXR) is a nuclear receptor that plays key roles...maintaining the homeostasis of liver metabolism. FXR null mice display strong hepatic inflammation...tumors. In this report, we demonstrate that FXR is a negative modulator of nuclear factor...

Article: Intercept Researchers Present Data at DDW Highlighting Role of FXR in Inflammatory Bowel Disease.
PR Newswire;  May 24, 2006 ;     700+ words ......role of the farnesoid X bile acid receptor (FXR) in inflammatory bowel disease. Intercept's lead FXR agonist, INT-747, is in Phase 1 clinical trials...results of studies demonstrating the role of FXR in the intestine in modulating the expression...

Article: Research from University of Pittsburgh has provided new data on cholestasis.
Biotech Week;  January 21, 2009 ;     491 words ......posttranslationally activated the farnesoid X receptor (FXR). Mechanisms underlying this regulation...United States report (see also Cholestasis). FXR function was assayed in response to wild-ty...phosphorylation and nuclear localization of FXR that was associated with FXR-dependent activation...

Article: Screening of novel nuclear receptor agonists by a convenient reporter gene assay system using green fluorescent protein derivatives.
Phytomedicine: International Journal of Phytotherapy & Phytopharmacology;  June 1, 2006 ;     700+ words ......receptors (RARs) and the farnesoid X receptor (FXR). In the reporter assay systems of nuclear...ligands of RARs, retinoid X receptor (RXR) and FXR. The screening using the reporter assay...were detected which activate RARs and/or FXR. Caffeic acid phenylethyl ester (CAPE...

Article: Reports from City of Hope National Medical Center advance knowledge in apoptosis cell biology.(Report)
Biotech Week;  August 13, 2008 ;     372 words ......a new report. The farnesoid X receptor (FXR) is a key metabolic regulator in the liver...metabolites. Recent findings suggest that FXR may have a much broader function in liver...present work, we identify a novel role of FXR in protecting liver cell from apoptosis...

Article: JNMC AND FXR SIGN LARGE CONCENTRATE SUPPLY CONTRACT
AsiaInfo Services;  March 15, 2004 ;     225 words ...AsiaInfo Services 03-15-2004 JNMC and FXR Sign Large Concentrate Supply Contract JINCHANG...Australian Fox Resource Limited (ASX Code: FXR) to buy nickel and copper concentrates from the latter. According to the contract, FXR will supply nickel and copper concentrates...

Article: Research reports on barrett esophagus from A. Capello and colleagues provide new insights.
Biotech Week;  July 30, 2008 ;     440 words ......toxic component. The farnesoid X receptor (FXR) is a nuclear receptor involved in the regulation...acid synthesis, transport, and absorption. FXR activation is also involved in the induction...innate immune response. This suggests that FXR is involved in the pathogenesis and the...

Article: Research from University of Kansas yields new data on colon cancer.
Cancer Weekly;  March 24, 2009 ;     445 words ......report (see also Colon Cancer). The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily, and bile acids are endogenous ligands of FXR. FXR is highly expressed in the intestine and liver where FXR...

Article: Harley puts itself to the test
Dealernews;  March 1, 1999 ;     565 words ......decide to once again start producing the FXR after they scrapped production of the bike...ease. It was clear that the oncepopular FXR would again be a welcome addition to the...Harley had in mind. "The mission behind the FXR was to test Harley-Davidson," says project...

Article: Research from University of Perugia in gastroenterology provides new insights.
Biotech Week;  April 1, 2009 ;     491 words ......ajpheart.01075.2008.-The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily...and fatty acid metabolism. The effect of FXR activation on aortic plaque formation was...E-deficient (ApoE(-)/(-)) mice with the synthetic FXR ligand INT-747, a cheno-deoxycholic acid...

Article: Research findings from University of Illinois update understanding of gene therapy.
Gene Therapy Weekly;  February 5, 2009 ;     450 words ......for ligand-activated farnesoid X receptor (FXR) induction of SHP,' is newly published data...bile acid receptor farnesoid X receptor (FXR) maintains lipid and glucose homeostasis...Using SHP as a model gene, we studied how FXR activity is regulated by p300 acetylase...

Article: X-Ceptor Therapeutics Announces Link With Cholesterol-Lowering Agents And the Orphan Nuclear Receptor, FXR.
PR Newswire;  May 3, 2002 ;     555 words ......and a specific protein called the Farnesoid X Receptor (FXR). FXR is an orphan nuclear receptor that has been identified as...extract from resin of the guggul tree, blocks the activity of FXR. The cholesterol lowering effects of guggulsterone have...

Article: New findings from University of Salamanca describe advances in physiology.
Biotech Week;  August 27, 2008 ;     515 words ......nucleus traffic and colocalization with FXR of conjugated bile acids in rat hepatocytes...receptors, in particular farnesoid X receptor (FXR). Whether, in addition to protein-mediated...involved in the access of BAs to nuclear FXR was investigated. When rat hepatocytes were...

Article: Farnesoid X receptor is essential for normal glucose homeostasis.(Research article)
Journal of Clinical Investigation;  April 1, 2006 ;     700+ words ...The bile acid receptor farnesoid X receptor (FXR; NR1H4) is a central regulator of bile acid and lipid metabolism. We show here that FXR plays a key regulatory role in glucose homeostasis. FXR-null mice developed severe fatty liver and elevated...