Article: The family that dies of insomnia For 200 years, chronic insomnia has killed half the members of an Italian dynasty. The family's efforts to understand this bizarre illness has, by chance, helped unravel the causes of CJD - a disease scientists fear is on the rise. D.T. Max reports

In 1791, in a small town near Venice, a man named Giacomo was born. Members of his family tended to be physically impressive, powerful and broad-shouldered (and still are today), but one day in the autumn of 1836, at the age of 45, Giacomo fell mysteriously ill. He began to suffer from dementia. Eventually he was confined to bed, lying awake in torment. Then he died.

Over the next century and a half, his descendants flourished. But running parallel with the family's affluence was an eerie record of premature death. Parish books over the decades noted oddities such as "epilepsy and fever" and "nervous gastric fever". Later, family death certificates would name meningitis, Economo's disease, ...

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