Article: Prozac Plus Talk Is Best for Teen Depression; Government-Funded Study Says Cognitive Behavior Therapy Boosts Drug's Benefits

The best treatment for depressed adolescents is a combination of Prozac and talk therapy, although the antidepressant does carry a risk that some patients might harm themselves or others, concluded a long-awaited study released yesterday.

Although the findings may seem contradictory, the study could begin to address the roiling controversy over the safety and effectiveness of antidepressants in children: Drugs such as Prozac might increase the risk that a minority of adolescents will harm themselves or others, even as they reduce depression among the majority.

The results will be weighed by regulators at the Food and Drug Administration, who have scheduled a meeting in September to ...

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