Article: Tranquilizer Reduces PMS Symptoms; Study Challenges Use of Progesterone to Treat Premenstrual Condition

Researchers have found that a common tranquilizer is "significantly better" than the most familiar treatment for severe premenstrual syndrome.

Compared with patients taking progesterone -- a female hormone widely prescribed for the 2 percent to 10 percent of women who experience severe PMS -- and with patients given a placebo, those treated with alprazolam (perhaps best known by its brand name Xanax) reported much greater improvement in symptoms.

By contrast, Philadelphia researchers report in today's issue of the Journal of the American Medical Association, "progesterone was ineffective in reducing the overall symptom distress of PMS, producing no greater degree of improvement than placebo."

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