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Article: Increased Plasma Markers of Oxidative Stress Are Associated with Coronary Heart Disease in Males with Diabetes Mellitus and with 10-Year Risk in a Prospective Sample of Males
- Article from:
- Clinical Chemistry
- Article date:
- March 1, 2006
- Author:
CopyrightCopyright American Association for Clinical Chemistry Mar 2006. Provided by ProQuest LLC. (Hide copyright information)
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Background: Increased oxidative stress is associated with coronary heart disease (CHD). We examined the association between plasma markers of oxidative stress and CHD in a cross-sectional sample of patients with diabetes and prospective CHD risk in a sample of men predominantly without diabetes.
Methods: Plasma total antioxidant status (TAOS) and the ratio of oxidized LDL (Ox-LDL) to LDL-cholesterol (LDL-C) were determined in a cross-section of 761 Caucasian individuals with diabetes (UDACS study). Plasma TAOS was also determined in 310 baseline samples from a 10-year prospective cohort of 3012 healthy males (NPHSII).
Results: Within UDACS, males with CHD had lower mean (SD) plasma TAOS [no ...