Article: Melatonin and Irritable Bowel Syndrome

Melatonin is involved in the regulation of the sleep-wake cycle, circadian rhythms, and seasonal changes in the light-dark cycle. Commonly used to induce sleep, some (but not all) find that melatonin reduces jet lag. There is a high concentration of melatonin in the pineal gland, where it is manufactured. I was surprised to learn there are significant amounts of melatonin present in the gastrointestinal tract. Apparently, melatonin helps regulate gastrointestinal motility.1

Those of you who do more than a site-specific history are well-aware of the number of people who suffer from irritable bowel syndrome (IBS). Epidemiological studies performed in the United States, the United Kingdom, and ...

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